Using parallels and, when in certain apps, could do with untying the keys that are bound to VoiceOver. The obvious thought is turning VoiceOver off only when I'm in that app, though I'm not sure if that is possible via an activity. I can do it manually, of course, but that's no fun. I've got an activity that mutes speech, which is good, but still hogs ctrl and option keys.
I'm basically setting my computer up as a duel Mac windows machine. Quick note, if you are going to dive into parallels, get it from their website, there are some very important features missing from the App Store version, namely the ability to treat windows apps like map apps and have them working in the same fashion as any other app on your Mac.