Admitedly I am new to RSS, I just never bothered with it before. But the fuss over Google Reader made me decide to take a look. I know there has been a lot of talk about Feedly, and I don't want to undermine the Campaign of the Month in any way, but I really do want to recommend Lire.
It seems very full featured and is incredibly simple to use. Also, the developer is very committed to VoiceOver support, just take a look at the release notes for the latest update to see that.
It's not free unfortunately, but if you're looking for a new RSS reader, I doubt you'll be disappointed with Lire.