Crash Course in MS Excel on MacBook

Hi folks,
I am starting a new job in a couple of weeks and anticipate it being heavy on MS Excel. I was a strong user before my eyesight descended into the low vision space and am pretty good at using voiceover within other MS apps and on my MacBook, in general.
Within Excel, I'm having some trouble identifying / using navigation within a worksheet.
I'd greatly appreciate the wisdom of the community on this topic, in any forum or format!
Thanks!